Article

Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis

2018-03-04

Abstract excerpt

Disseminated tumor cells (DTCs) are recognized as the seeds of metastasis. However, metastatic lesions can become symptomatic years or decades after primary tumor removal. This clinical finding suggests that DTCs are not immediately competent to initiate growth and can persist in a dormant state. Here we review recent data for three potential scenarios that could result in DTC dormancy: (a) The target organ microe...

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Literature Corpus work: c102dd94-c8ff-5b80-bcbd-1f7676f1dcd1
DOI: 10.1146/annurev-cancerbio-030617-050446

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