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Article

Tumor Dormancy and Relapse: From a Natural Byproduct of Evolution to a Disease State

14 May 2017

Abstract excerpt

Abstract Species evolve by mutations and epigenetic changes acting on individuals in a population; tumors evolve by similar mechanisms at a cellular level in a tissue. This article reviews growing evidence about tumor dormancy and suggests that (i) cellular malignancy is a natural byproduct of evolutionary mechanisms, such as gene mutations and epigenetic modifications, which is manifested in the form of tumor...

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Identifiers

PMID: 28507050
DOI: 10.1158/0008-5472.can-17-0068

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