Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21

13 Aug 2020

Abstract excerpt

BACKGROUND: ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result of recurrent chromosomal translocations. In human prostate cell lines, ETV4 promotes migration, invasion, and proliferation; however, its role in PC has been unclear. In this study, we have explored the effects of ETV4 expression in the prostate in a novel transgenic mouse model. METHODS: We have created a mouse model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32791988
DOI: 10.1186/s13045-020-00943-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21PMID 32791988Read ↗

ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancerSemantic proximity Read ↗

Overexpression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transitionSemantic proximity Read ↗

<i>ETV4</i> promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancerSemantic proximity Read ↗

Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate CancerSemantic proximity Read ↗

Induction of Prostatic Intraepithelial Neoplasia and Modulation of Androgen Receptor by ETS Variant 1/ETS-Related Protein 81Semantic proximity Read ↗

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.Semantic proximity Read ↗

14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer.Semantic proximity Read ↗

MYC and Prostate CancerSemantic proximity Read ↗

ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cellsSemantic proximity Read ↗

Truncated ETV1, Fused to Novel Tissue-Specific Genes, and Full-Length ETV1 in Prostate CancerSemantic proximity Read ↗

Mechanistic insights of epithelial protein lost in neoplasm in prostate cancer metastasisSemantic proximity Read ↗

Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.