Article
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
Cancer discovery - 1 May 2015
Lunardi Andrea, Varmeh Shohreh, Chen Ming, Taulli Riccardo, Guarnerio Jlenia, Ala Ugo, Seitzer Nina, Ishikawa Tomoki, Carver Brett S, Hobbs Robin M, Quarantotti Valentina, Ng Christopher, Berger Alice H, Nardella Caterina, Poliseno Laura, Montironi Rodolfo, Castillo-Martin Mireia, Cordon-Cardo Carlos, Signoretti Sabina, Pandolfi Pier Paolo
Abstract excerpt
UNLABELLED: The ETS family of transcription factors has been repeatedly implicated in tumorigenesis. In prostate cancer, ETS family members, such as ERG, ETV1, ETV4, and ETV5, are frequently overexpressed due to chromosomal translocations, but the molecular mechanisms by which they promote prostate tumorigenesis remain largely undefined. Here, we show that ETS family members, such as ERG and ETV1, directly...
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