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Article

14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer.

Cancer research - 15 Aug 2013

Oh Sangphil, Shin Sook, Lightfoot Stan A, Janknecht Ralf

Abstract excerpt

Overexpression of the ETS-related transcription factor ETV1 can initiate neoplastic transformation of the prostate. ETV1 activity is highly regulated by phosphorylation, but the underlying mechanisms are unknown. Here we report that all 14-3-3 proteins, with the exception of the tumor suppressor 14-3-3σ, can bind to ETV1 in a condition manner dictated by its prominent phosphorylation site S216. Non-σ 14-3-3...

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Source

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Identifiers

PMID: 23774214
DOI: 10.1158/0008-5472.CAN-13-0578
PMCID: PMC3745528

Genes

ETV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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