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Article

Bacterial polyphosphates interfere with the innate host defense to infection.

Nature communications - 12 Aug 2020

Roewe Julian, Stavrides Georgios, Strueve Marcel, Sharma Arjun, Marini Federico, Mann Amrit, Smith Stephanie A, Kaya Ziya, Strobl Birgit, Mueller Mathias, Reinhardt Christoph, Morrissey James H, Bosmann Markus

Abstract excerpt

Polyphosphates are linear polymers and ubiquitous metabolites. Bacterial polyphosphates are long chains of hundreds of phosphate units. Here, we report that mouse survival of peritoneal Escherichia coli sepsis is compromised by long-chain polyphosphates, and improves with bacterial polyphosphatekinase deficiency or neutralization using recombinant exopolyphosphatase. Polyphosphate activities are chain-length...

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Identifiers

PMID: 32788578
DOI: 10.1038/s41467-020-17639-x
PMCID: PMC7423913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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