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The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.

Communications biology - 17 Feb 2026

Moberget Torgeir, van der Meer Dennis, Bahrami Shahram, Roelfs Daniel, Frei Oleksandr, Kaufmann Tobias, Fernandez-Cabello Sara, Kim Milin, Wolfers Thomas, Diedrichsen Joern, Smeland Olav B, Shadrin Alexey, Dale Anders, Andreassen Ole A, Westlye Lars T

Abstract excerpt

The functional domain of the cerebellum has expanded beyond motor control to also include cognitive and affective functions. In line with this notion, cerebellar volume has increased over recent primate evolution, and cerebellar alterations have been linked to heritable mental disorders. To map the genetic architecture of human cerebellar morphology, we here studied a large imaging genetics sample from the UK...

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Identifiers

PMID: 41703085
DOI: 10.1038/s42003-026-09664-1
PMCID: PMC13021948

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