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Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility

11 Aug 2020

Abstract excerpt

BACKGROUND: Gene drives based on CRISPR-Cas9 technology are increasingly being considered as tools for reducing the capacity of mosquito populations to transmit malaria, and one of the most promising options is driving endonuclease genes that reduce the fertility of female mosquitoes. In particular, there is much interest in constructs that target the conserved mosquito doublesex (dsx) gene such that the...

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PMID: 32782000
DOI: 10.1186/s12915-020-00834-z

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