MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations

Abstract excerpt

Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its demonstrated ability to streamline the development of gene drive systems has reignited interest in the application of this technology to the contro...

Topics

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• Alleles
• Anopheles
• CRISPR and Genetic Engineering
• Inheritance Patterns
• Insect symbiosis and bacterial influences
• Malaria
• Mosquito-borne diseases and control
• Mosquito Vectors

Identifiers and source

Literature Corpus work

cc2e74db-283d-5544-81cf-e099968e92b5

DOI

10.1101/350488