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Article

Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure.

eLife - 14 Oct 2022

Champer Samuel E, Kim Isabel K, Clark Andrew G, Messer Philipp W, Champer Jackson

Abstract excerpt

Recent experiments have produced several Anopheles gambiae homing gene drives that disrupt female fertility genes, thereby eventually inducing population collapse. Such drives may be highly effective tools to combat malaria. One such homing drive, based on the zpg promoter driving CRISPR/Cas9, was able to eliminate a cage population of mosquitoes. A second version, purportedly improved upon the first by...

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Identifiers

PMID: 36239372
DOI: 10.7554/eLife.79121
PMCID: PMC9596161

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