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Article

Atomistic simulation reveals structural mechanisms underlying D614G spike glycoprotein-enhanced fitness in SARS-COV-2.

Journal of computational chemistry - 15 Sept 2020

Omotuyi I Olaposi, Nash Oyekanmi, Ajiboye O Basiru, Iwegbulam C Gift, Oyinloye E Babatunji, Oyedeji O Abimbola, Kashim Z Abimbola, Okaiyeto Kunle

Abstract excerpt

D614G spike glycoprotein (sgp) mutation in rapidly spreading severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) is associated with enhanced fitness and higher transmissibility in new cases of COVID-19 but the underlying mechanism is unknown. Here, using atomistic simulation, a plausible mechanism has been delineated. In G614 sgp but not wild type, increased D(G)614-T859 Cα-distance within 65 ns is...

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Identifiers

PMID: 32779780
DOI: 10.1002/jcc.26383
PMCID: PMC7404873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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