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Article

The SARS-CoV-2 Spike variant D614G favors an open conformational state.

Science advances - 1 Apr 2021

Mansbach Rachael A, Chakraborty Srirupa, Nguyen Kien, Montefiori David C, Korber Bette, Gnanakaran S

Abstract excerpt

The COVID-19 (coronavirus disease 2019) pandemic underwent a rapid transition with the emergence of a dominant viral variant (from the "D-form" to the "G-form") that carried an amino acid substitution D614G in its "Spike" protein. The G-form is more infectious in vitro and is associated with increased viral loads in the upper airways. To gain insight into the molecular-level underpinnings of these...

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Source

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Identifiers

PMID: 33863729
DOI: 10.1126/sciadv.abf3671
PMCID: PMC8051874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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