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Article

Polygenic modelling of treatment effect heterogeneity.

Genetic epidemiology - 1 Nov 2020

Xu Zhi Ming, Burgess Stephen

Abstract excerpt

Mendelian randomization is the use of genetic variants to assess the effect of intervening on a risk factor using observational data. We consider the scenario in which there is a pharmacomimetic (i.e., treatment-mimicking) genetic variant that can be used as a proxy for a particular pharmacological treatment that changes the level of the risk factor. If the association of the pharmacomimetic genetic variant with...

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Identifiers

PMID: 32779269
DOI: 10.1002/gepi.22347
PMCID: PMC7612928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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