PLA2G6 variants associated with the number of affected alleles in Parkinson's disease in Japan.

doi:10.1016/j.neurobiolaging.2020.07.004

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Article

PLA2G6 variants associated with the number of affected alleles in Parkinson's disease in Japan.

Neurobiology of aging - 1 Jan 2021

Daida Kensuke, Nishioka Kenya, Li Yuanzhe, Yoshino Hiroyo, Shimada Tomoyo, Dougu Nobuhiro, Nakatsuji Yuji, Ohara Shinji, Hashimoto Takao, Okiyama Ryoichi, Yokochi Fusako, Suzuki Chieko, Tomiyama Masahiko, Kimura Katsuo, Ueda Naohisa, Tanaka Fumiaki, Yamada Hitoshi, Fujioka Shinsuke, Tsuboi Yoshio, Uozumi Takenori, Takei Takanobu, Matsuzaki Shigeru, Shibasaki Morikazu, Kashihara Kenichi, Kurisaki Ryoichi, Yamashita Tetsuji, Fujita Nobuya, Hirata Yoshinori, Ii Yuichiro, Wada Chizu, Eura Nobuyuki, Sugie Kazuma, Higuchi Yujiro, Kojima Fumikazu, Imai Hisamasa, Noda Kazuyuki, Shimo Yasushi, Funayama Manabu, Hattori Nobutaka

Abstract excerpt

This study aimed to evaluate genotype-phenotype correlations of Parkinson's disease (PD) patients with phospholipase A2 group V (PLA2G6) variants. We analyzed the DNA of 798 patients with PD, including 78 PD patients reported previously, and 336 in-house controls. We screened the exons and exon-intron boundaries of PLA2G6 using the Ion Torrent system and Sanger method. We identified 21 patients with 18 rare...

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PMID: 32771225
DOI: 10.1016/j.neurobiolaging.2020.07.004

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