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Association of rare heterozygous PLA2G6 variants with the risk of Parkinson's disease.

Neurobiology of aging - 1 May 2021

Liu Hongli, Wang Yige, Pan Hongxu, Xu Kun, Jiang Li, Zhao Yuwen, Xu Qian, Sun Qiying, Tan Jieqiong, Yan Xinxiang, Li Jinchen, Tang Beisha, Guo Jifeng

Abstract excerpt

The PLA2G6 gene has been identified as a causative gene for autosomal recessive early-onset dystonia-parkinsonism. Possible association was reported between single heterozygous PLA2G6 mutation and the risk of Parkinson's disease (PD), which, however, remained inconclusive. To clarify the effect of heterozygous PLA2G6 variants on the risk of PD, a total of 3710 patients with PD and 2636 controls of Chinese...

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PMID: 33279242
DOI: 10.1016/j.neurobiolaging.2020.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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