Genomic and Transcriptomic Profile of HNF1A-Mutated Liver Adenomas Highlights Molecular Signature and Potential Therapeutic Implications.

doi:10.3390/ijms251910483

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Genomic and Transcriptomic Profile of HNF1A-Mutated Liver Adenomas Highlights Molecular Signature and Potential Therapeutic Implications.

International journal of molecular sciences - 29 Sept 2024

Faini Angelo Corso, Arruga Francesca, Pinon Michele, Bracciamà Valeria, Vallone Francesco Edoardo, Mioli Fiorenza, Sorbini Monica, Migliorero Martina, Gambella Alessandro, Carota Damiano, Giraudo Isaac, Cassoni Paola, Catalano Silvia, Romagnoli Renato, Amoroso Antonio, Calvo Pier Luigi, Vaisitti Tiziana, Deaglio Silvia

Abstract excerpt

Hepatocellular adenomas (HAs) are tumors that can develop under different conditions, including in patients harboring a germline mutation in HNF1A. However, little is known about the pathogenesis of such disease. This work aims to better define what mechanisms lie under the development of this condition. Six HAs were sampled from the liver of a 17-year-old male affected by diabetes and multiple hepatic...

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PMID: 39408812
DOI: 10.3390/ijms251910483
PMCID: PMC11477380

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