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Article

Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2.

Life sciences - 15 Oct 2020

Mohammad Anwar, Marafie Sulaiman K, Alshawaf Eman, Abu-Farha Mohamed, Abubaker Jehad, Al-Mulla Fahd

Abstract excerpt

AIMS: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel member of the betacoronaviruses family affecting the lower respiratory tract mainly through binding to angiotensin converting enzyme 2 (ACE2) via its S-protein. Genetic analysis of (ACE2) gene revealed several variants that have been suggested to regulate the interaction with S protein. This study investigates the N720D variant,...

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Source

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Identifiers

PMID: 32768580
DOI: 10.1016/j.lfs.2020.118219
PMCID: PMC7405906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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