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Origin of the tight binding mode to ACE2 triggered by multi-point mutations in the omicron variant: a dynamic insight.

Physical chemistry chemical physics : PCCP - 13 Apr 2022

Zhao Xiaoyu, Xiong Danyang, Luo Song, Duan Lili

Abstract excerpt

The continuous spread of the newly emerged SARS-CoV-2 Omicron variant (B.1.1.529) has become an important reason for the surge in COVID-19 infections. Its numerous mutated residues containing key sites on the receptor-binding domain (RBD) undoubtedly pose new challenges for epidemic control. Although the preventive measures are becoming more sophisticated, the effects of mutations on the binding of the virus to...

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PMID: 35373810
DOI: 10.1039/d2cp00449f

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