Article
Multiple ways to a dead end: diverse mechanisms by which ALS mutant genes induce cell death.
Cell cycle (Georgetown, Tex.) - 1 Apr 2021
Tsai Yueh-Lin, Manley James L
Abstract excerpt
Amyotrophic Lateral Sclerosis (ALS) is a deadly neuromuscular disorder caused by progressive motor neuron loss in the brain and spinal cord. Over the past decades, a number of genetic mutations have been identified that cause or are associated with ALS disease progression. Numerous genes harbor ALS mutations, and they encode proteins displaying a wide range of physiological functions, with limited overlap....
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- Autophagy
- C9orf72 Protein
- Cell Death
- DNA Damage
- DNA-Binding Proteins
- Humans
- Mutation
- RNA-Binding Protein FUS