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Article

Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue.

mBio - 19 Aug 2014

Palace Samantha G, Proulx Megan K, Lu Shan, Baker Richard E, Goguen Jon D

Abstract excerpt

UNLABELLED: Rapid growth in deep tissue is essential to the high virulence of Yersinia pestis, causative agent of plague. To better understand the mechanisms underlying this unusual ability, we used transposon mutagenesis and high-throughput sequencing (Tn-seq) to systematically probe the Y. pestis genome for elements contributing to fitness during infection. More than a million independent insertion mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25139902
DOI: 10.1128/mBio.01385-14
PMCID: PMC4147864

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