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Article

Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300

5 Aug 2020

Abstract excerpt

Genomic analysis revealed that EP300 is highly enriched at enhancers associated with genes involved in multiple profibrotic pathways, and broad transcriptomic and proteomic profiling of CREBBP/EP300 inhibition by the chemical probe SGC-CBP30 identified collagen VI (Col VI) as a prominent downstream regulator of myofibroblast activity. Targeted Col VI knockdown results in significant decrease in profibrotic...

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PMID: 32759223
DOI: 10.1073/pnas.2004281117

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