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Article

The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis.

Cell death & disease - 25 Apr 2013

Sampurno S, Bijenhof A, Cheasley D, Xu H, Robine S, Hilton D, Alexander W S, Pereira L, Mantamadiotis T, Malaterre J, Ramsay R G

Abstract excerpt

The gastrointestinal (GI) epithelium is constantly renewing, depending upon the intestinal stem cells (ISC) regulated by a spectrum of transcription factors (TFs), including Myb. We noted previously in mice with a p300 mutation (plt6) within the Myb-interaction-domain phenocopied Myb hypomorphic mutant mice with regard to thrombopoiesis, and here, changes in GI homeostasis. p300 is a transcriptional coactivator...

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Identifiers

PMID: 23618903
DOI: 10.1038/cddis.2013.119
PMCID: PMC3641342

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ATF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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