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Transcellular transmission and molecular heterogeneity of aggregation-prone proteins in neurodegenerative diseases

4 Jul 2024

Abstract excerpt

The accumulation of aggregation-prone proteins in a specific neuronal population is a common feature of neurodegenerative diseases, which is correlated with the development of pathological lesions in diseased brains. The formation and progression of pathological protein aggregates in susceptible neurons induce cellular dysfunction, resulting in progressive degeneration. Moreover, recent evidence supports the...

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PMID: 38971320
DOI: 10.1016/j.mocell.2024.100089

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