Baseline Uncommon EGFR Mutations in Non-Small-Cell Lung Cancer: Structure-Function Classification and Clinical Evidence Interpretation.

Abstract excerpt

In this narrative review, we examine baseline uncommon epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) through a structure-function classification framework and clinical evidence interpretation. Baseline uncommon EGFR mutations are molecularly heterogeneous, and exon-based classification alone cannot fully capture their structural diversity or variable sensitivity to...

Topics

• Humans
• ErbB Receptors
• Carcinoma, Non-Small-Cell Lung
• Mutation
• Lung Neoplasms
• Protein Kinase Inhibitors