Article
Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer cell - 11 Apr 2016
Foster Scott A, Whalen Daniel M, Özen Ayşegül, Wongchenko Matthew J, Yin JianPing, Yen Ivana, Schaefer Gabriele, Mayfield John D, Chmielecki Juliann, Stephens Philip J, Albacker Lee A, Yan Yibing, Song Kyung, Hatzivassiliou Georgia, Eigenbrot Charles, Yu Christine, Shaw Andrey S, Manning Gerard, Skelton Nicholas J, Hymowitz Sarah G, Malek Shiva
Abstract excerpt
Activating mutations in protein kinases drive many cancers. While how recurring point mutations affect kinase activity has been described, the effect of in-frame deletions is not well understood. We show that oncogenic deletions within the β3-αC loop of HER2 and BRAF are analogous to the recurrent EGFR exon 19 deletions. We identify pancreatic carcinomas with BRAF deletions mutually exclusive with KRAS mutations....
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