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Article

Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer communications (London, England) - 1 Jan 2020

Liu Haijing, Zhang Bo, Sun Zhifu

Abstract excerpt

BACKGROUND: Human epidermal growth factor receptor (EGFR) is an oncogenic gene and one of top targets of precision therapy in lung cancer with EGFR mutations. Although there are many reports for some individual cancers, comprehensive profiling of EGFR mutations, overexpression, amplification, DNA methylation, and their clinical associations across many different cancers simultaneously was not available. This...

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Identifiers

PMID: 32067422
DOI: 10.1002/cac2.12005
PMCID: PMC7163653

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