Article
Human Cardiac Mesenchymal Stem Cells Remodel in Disease and Can Regulate Arrhythmia Substrates.
Circulation. Arrhythmia and electrophysiology - 1 Oct 2020
Sattayaprasert Prasongchai, Vasireddi Sunil K, Bektik Emre, Jeon Oju, Hajjiri Mohammad, Mackall Judith A, Moravec Christine S, Alsberg Eben, Fu Jidong, Laurita Kenneth R
Abstract excerpt
BACKGROUND: The mesenchymal stem cell (MSC), known to remodel in disease and have an extensive secretome, has recently been isolated from the human heart. However, the effects of normal and diseased cardiac MSCs on myocyte electrophysiology remain unclear. We hypothesize that in disease the inflammatory secretome of cardiac human MSCs (hMSCs) remodels and can regulate arrhythmia substrates. METHODS: hMSCs were...
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