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Article

Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.

American journal of physiology. Heart and circulatory physiology - 15 Sept 2013

Ivashchenko Christine Y, Pipes Gordon C, Lozinskaya Irina M, Lin Zuojun, Xiaoping Xu, Needle Saul, Grygielko Eugene T, Hu Erding, Toomey John R, Lepore John J, Willette Robert N

Abstract excerpt

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) have been recently derived and are used for basic research, cardiotoxicity assessment, and phenotypic screening. However, the hiPS-CM phenotype is dependent on their derivation, age, and culture conditions, and there is disagreement as to what constitutes a functional hiPS-CM. The aim of the present study is to characterize the temporal changes...

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Identifiers

PMID: 23832699
DOI: 10.1152/ajpheart.00819.2012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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