Emergence of antibiotic-specific Mycobacterium tuberculosis phenotypes during prolonged treatment of mice

Abstract excerpt

ABSTRACT A major challenge in tuberculosis (TB) therapeutics is that antibiotic exposure leads to changes in the physiology of M. tuberculosis ( Mtb ), which may enable the pathogen to withstand treatment. While antibiotic-treated Mtb has been evaluated in in vitro experiments , it is unclear if and how long-term in vivo treatment with diverse antibiotics with varying treatment-shortening activity (sterilizing...

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