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Article

Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.

Communications biology - 3 Aug 2020

Li Tao, He Lihui, Li Changcheng, Kang Mei, Song Yingjie, Zhu Yibo, Shen Yalin, Zhao Ninglin, Zhao Chang, Yang Jing, Huang Qin, Mou Xingyu, Tong Aiping, Yang Jinliang, Wang Zhenling, Ji Chengjie, Li Hong, Tang Hong, Bao Rui

Abstract excerpt

MucA and MucB are critical negative modulators of sigma factor AlgU and regulate the mucoid conversion of Pseudomonas aeruginosa. Previous studies have revealed that lipid signals antagonize MucA-MucB binding. Here we report the crystal structure of MucB in complex with the periplasmic domain of MucA and polyethylene glycol (PEG), which unveiled an intermediate state preceding the MucA-MucB dissociation. Based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32747658
DOI: 10.1038/s42003-020-01147-1
PMCID: PMC7400510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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