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Article

Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism.

Molecular microbiology - 1 Aug 2014

de Regt Anna K, Yin Yeshi, Withers T Ryan, Wang Xin, Baker Tania A, Sauer Robert T, Yu Hongwei D

Abstract excerpt

In Pseudomonas aeruginosa, alginate overproduction, also known as mucoidy, is negatively regulated by the transmembrane protein MucA, which sequesters the alternative sigma factor AlgU. MucA is degraded via a proteolysis pathway that frees AlgU from sequestration, activating alginate biosynthesis. Initiation of this pathway normally requires two signals: peptide sequences in unassembled outer-membrane proteins...

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PMID: 24913916
DOI: 10.1111/mmi.12665
PMCID: PMC4116675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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