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Nucleocapsid Protein Precursors NCp9 and NCp15 Suppress ATP-Mediated Rescue of AZT-Terminated Primers by HIV-1 Reverse Transcriptase.

Antimicrobial agents and chemotherapy - 21 Sept 2020

Árquez Moisés A, Martín-Alonso Samara, Gorelick Robert J, Scott Walter A, Acosta-Hoyos Antonio J, Menéndez-Arias Luis

Abstract excerpt

In HIV-1, development of resistance to AZT (3'-azido-3'-deoxythymidine) is mediated by the acquisition of thymidine analogue resistance mutations (TAMs) (i.e., M41L, D67N, K70R, L210W, T215F/Y, and K219E/Q) in the viral reverse transcriptase (RT). Clinically relevant combinations of TAMs, such as M41L/T215Y or D67N/K70R/T215F/K219Q, enhance the ATP-mediated excision of AZT monophosphate (AZTMP) from the 3' end of...

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PMID: 32747359
DOI: 10.1128/AAC.00958-20
PMCID: PMC7508609

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