Article
HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2008
Delviks-Frankenberry Krista A, Nikolenko Galina N, Boyer Paul L, Hughes Stephen H, Coffin John M, Jere Abhay, Pathak Vinay K
Abstract excerpt
We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test the predictions of this model, we analyzed the effects of previously identified cn mutations in combination with thymidine analog mutations (D67N, K70R, T215Y, and K219Q) on in vitro RNase H activity...
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