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Article

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

30 Sept 2020

Abstract excerpt

Interleukin (IL)-18 and IL-1β are potent pro-inflammatory cytokines that contribute to inflammatory conditions such as rheumatoid arthritis and Alzheimer’s disease. They are produced as inactive precursors that are activated by large macromolecular complexes called inflammasomes upon sensing damage or pathogenic signals. NLRP3 inflammasome activation is regarded to require a priming step that causes NLRP3 and...

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PMID: 33101286
DOI: 10.3389/fimmu.2020.565924

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