Article
Significance of oncogenes and tumor suppressor genes in AML prognosis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2016
Kavianpour Maria, Ahmadzadeh Ahmad, Shahrabi Saeid, Saki Najmaldin
Abstract excerpt
Acute myeloid leukemia (AML) is a heterogeneous disorder among hematologic malignancies. Several genetic alterations occur in this disease, which cause proliferative progression, reducing differentiation and apoptosis in leukemic cells as well as increasing their survival. In the genetic study of AML, genetic translocations, gene overexpression, and mutations effective upon biology and pathogenesis of this...
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