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Article

Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males

7 May 2020

Abstract excerpt

Couples are delaying childbearing in recent decades. While women experience a notable decrease in oocyte production in their late thirties, the effect of advanced paternal age on reproduction is incompletely understood. Herein, we observed that numerous miRNAs, including miR-574, increased in the sperm of aging males, as indicated by high-throughput sequencing. We demonstrated that miR-574 was upregulated in the...

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PMID: 32381753
DOI: 10.18632/aging.103141

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