Article
Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2020
Ge Yichen, Wu Fuguo, Cheng Mobin, Bard Jonathan, Mu Xiuqian
Abstract excerpt
BACKGROUND: During development, all retinal cell types arise from retinal progenitor cells (RPCs) in a step-wise fashion. Atoh7 and Pou4f2 mark, and function in, two phases of retinal ganglion cell (RGC) genesis; Atoh7 functions in a subpopulation of RPCs to render them competent for the RGC fate, whereas Pou4f2 participates in RGC fate specification and RGC differentiation. Despite extensive research on their...
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