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Article

Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015

Wu Fuguo, Kaczynski Tadeusz J, Sethuramanujam Santhosh, Li Renzhong, Jain Varsha, Slaughter Malcolm, Mu Xiuqian

Abstract excerpt

As with other retinal cell types, retinal ganglion cells (RGCs) arise from multipotent retinal progenitor cells (RPCs), and their formation is regulated by a hierarchical gene-regulatory network (GRN). Within this GRN, three transcription factors--atonal homolog 7 (Atoh7), POU domain, class 4, transcription factor 2 (Pou4f2), and insulin gene enhancer protein 1 (Isl1)--occupy key node positions at two different...

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PMID: 25775587
DOI: 10.1073/pnas.1421535112
PMCID: PMC4386335

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