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Article

The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development

17 Aug 2020

Abstract excerpt

Significance Vertebrate retinal ganglion cells (RGCs) transmit all visual signals from the eye to the brain, are the pathogenic target in glaucoma, and require the Atoh7 competence factor to develop from multipotent progenitors. Atoh7 transcription is controlled by dual cis regulatory elements, including a remote shadow enhancer (SE). In humans, loss of the SE causes NCRNA disease, with congenital blindness due...

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PMID: 32817515
DOI: 10.1073/pnas.2006888117

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The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell developmentPMID 32817515Read ↗

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