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Article

Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain

16 Jul 2020

Abstract excerpt

Skp1, a component of the ubiquitin E3 ligases, was found to be decreased in the brains of sporadic Parkinson's disease (PD) patients, and its overexpression prevented death of murine neurons in culture. Here we expose the neuroprotective role of the Drosophila skp1 homolog, skpA, in the adult brain. Neuronal knockdown of skpA leads to accumulation of ubiquitinated protein aggregates and loss of dopaminergic...

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PMID: 32739834
DOI: 10.1016/j.isci.2020.101375

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