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Article

Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease.

Parkinsonism & related disorders - 1 Jan 2012

Mandel Silvia A, Fishman-Jacob Tali, Youdim Moussa B H

Abstract excerpt

AIMS: To assess whether reduction of Skp1 will increase the vulnerability of dopaminergic neurons to genetic/environmental factors known to play a role in the pathological process of PD. METHODS: Short hairpin RNA lentiviruses infection of substantia nigra (SN)-derived cell-line (SN4741) and mice intranigral injection. RESULTS: We have knocked down the expression of SKP1A, an E3 ubiquitin ligase element, found...

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PMID: 22166427
DOI: 10.1016/S1353-8020(11)70055-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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