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Protein sumoylation with SUMO1 promoted by Pin1 in glioma stem cells augments glioblastoma malignancy

19 Jun 2020

Abstract excerpt

BACKGROUND: The tumorigenic potential of glioma stem cells (GSCs) is associated with multiple reversible molecular alternations, but the role of posttranslational protein sumoylation in GSCs has not been elucidated. The development of GSC-targeting drugs relies on the discovery of GSC-preferential molecular modifications and the relevant signaling pathways. In this work, we investigated the protein sumoylation...

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PMID: 32592588
DOI: 10.1093/neuonc/noaa150

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