Article
MutEnricher: a flexible toolset for somatic mutation enrichment analysis of tumor whole genomes.
BMC bioinformatics - 31 Jul 2020
Soltis Anthony R, Dalgard Clifton L, Pollard Harvey B, Wilkerson Matthew D
Abstract excerpt
BACKGROUND: Analysis of somatic mutations from tumor whole exomes has fueled discovery of novel cancer driver genes. However, ~ 98% of the genome is non-coding and includes regulatory elements whose normal cellular functions can be disrupted by mutation. Whole genome sequencing (WGS), on the other hand, allows for identification of non-coding somatic variation and expanded estimation of background mutation rates,...
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