Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct lineage tracing reveals Activin-a potential for improved pancreatic homing of bone marrow mesenchymal stem cells and efficient ß-cell regeneration in vivo

30 Jul 2020

Abstract excerpt

Abstract Background Despite the potential, bone marrow-derived mesenchymal stem cells (BMSCs) show limitations for beta (ß)-cell replacement therapy due to inefficient methods to deliver BMSCs into pancreatic lineage. In this study, we report TGF-ß family member protein, Activin-a potential to stimulate efficient pancreatic migration, enhanced homing and accelerated ß-cell differentiation. Methods Lineage tracing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Pancreatic function and diabetes
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32731883
DOI: 10.1186/s13287-020-01843-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct lineage tracing reveals Activin-a potential for improved pancreatic homing of bone marrow mesenchymal stem cells and efficient ß-cell regeneration in vivoPMID 32731883Read ↗

Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic DuctsSemantic proximity Read ↗

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animalsSemantic proximity Read ↗

From iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements With Vitamin C and Retinoic Acid in Diabetes ResearchSemantic proximity Read ↗

Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challengesSemantic proximity Read ↗

Generating pancreatic β-cells from embryonic stem cells by manipulating signaling pathwaysSemantic proximity Read ↗

Lineage Tracing Evidence for In Vitro Dedifferentiation but Rare Proliferation of Mouse Pancreatic β-CellsSemantic proximity Read ↗

Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cellsSemantic proximity Read ↗

<i>glucagon</i> is essential for alpha cell transdifferentiation and beta cell neogenesisSemantic proximity Read ↗

Pdx1 (GFP/w) mice for isolation, characterization, and differentiation of pancreatic progenitor cells.Semantic proximity Read ↗

Recent Advances and Prospects in the Differentiation of Pancreatic Cells From Human Embryonic Stem CellsSemantic proximity Read ↗

Generation of pancreatic progenitors from human pluripotent stem cells by small moleculesSemantic proximity Read ↗

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.