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Article

In vitro identification of drugs inducing systemic hypersensitivity reactions known in vivo to be associated with specific HLA genotypes.

Toxicology in vitro : an international journal published in association with BIBRA - 1 Oct 2020

Iulini Martina, Maddalon Ambra, Galbiati Valentina, Marinovich Marina, Corsini Emanuela

Abstract excerpt

Hypersensitivity drug reactions (HDRs) are common among drugs, despite this, there are no validated in vitro or in vivo methods for screening the sensitizing potential of drugs in the preclinical phase. We previously developed the THP-1 activation assay, based on CD86 upregulation and IL-8 production, for the in vitro identification of drugs able to induce selective dendritic cell activation. In this paper, we...

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Identifiers

PMID: 32730864
DOI: 10.1016/j.tiv.2020.104953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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