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Article

Identifying adaptive alleles in the human genome: from selection mapping to functional validation.

Human genetics - 1 Feb 2021

Werren Elizabeth A, Garcia Obed, Bigham Abigail W

Abstract excerpt

The suite of phenotypic diversity across geographically distributed human populations is the outcome of genetic drift, gene flow, and natural selection throughout human evolution. Human genetic variation underlying local biological adaptations to selective pressures is incompletely characterized. With the emergence of population genetics modeling of large-scale genomic data derived from diverse populations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32728809
DOI: 10.1007/s00439-020-02206-7

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