The MTHFR C677T polymorphism contributes to increased risk of Alzheimer's disease: evidence based on 40 case-control studies.

doi:10.1016/j.neulet.2014.11.049

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Article

The MTHFR C677T polymorphism contributes to increased risk of Alzheimer's disease: evidence based on 40 case-control studies.

Neuroscience letters - 23 Jan 2015

Peng Qiliu, Lao Xianjun, Huang Xiuli, Qin Xue, Li Shan, Zeng Zhiyu

Abstract excerpt

The association between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and Alzheimer's Disease (AD) risk has been widely reported with inconsistent results. We performed an updated meta-analysis of all available studies to clarify this situation. We conducted a comprehensive literature search in PubMed Alzgene, Embase, and Chinese Biomedical Literature database (CBM) for the period up to June...

Topics

Alzheimer Disease
Apolipoprotein E4
Case-Control Studies
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 25486592
DOI: 10.1016/j.neulet.2014.11.049

Genes

MTHFR
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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