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Article

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1

3 Jul 2020

Abstract excerpt

The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely-studied to test candidate leukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed Cap Analysis of Gene Expression (CAGE) to analyse a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96...

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PMID: 32719792
DOI: 10.3389/fcell.2020.00498

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