Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-dependent regional retinal nerve fibre changes in SIX1/SIX6 polymorphism.

Scientific reports - 27 Jul 2020

Charng Jason, Simcoe Mark, Sanfilippo Paul G, Allingham R Rand, Hewitt Alex W, Hammond Chris J, Mackey David A, Yazar Seyhan

Abstract excerpt

SIX1/SIX6 polymorphism has been shown to be associated with glaucoma. Studies have also found that, in older adults, retinal nerve fibre layer (RNFL) thickness is significantly thinned with each copy of the risk allele in SIX1/SIX6. However, it is not known whether these genetic variants exert their effects in younger individuals. Comparing a healthy young adult with an older adult cohort (mean age 20 vs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aging
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Nerve Fibers

Share to Retina

Share to Trans-Activators

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 32719476
DOI: 10.1038/s41598-020-69524-8
PMCID: PMC7385166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-dependent regional retinal nerve fibre changes in SIX1/SIX6 polymorphism.PMID 32719476Read ↗

Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children.Semantic proximity Read ↗

Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.Semantic proximity Read ↗

Association of Polymorphisms at the SIX1/SIX6 Locus With Normal Tension Glaucoma in a Korean Population.Semantic proximity Read ↗

Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study.Semantic proximity Read ↗

A Common Glaucoma-risk Variant of SIX6 Alters Retinal Nerve Fiber Layer and Optic Disc Measures in a European Population: The EPIC-Norfolk Eye Study.Semantic proximity Read ↗

Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the Chinese population.Semantic proximity Read ↗

Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma.Semantic proximity Read ↗

Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age.Semantic proximity Read ↗

Lack of association between SIX1/SIX6 locus polymorphisms and pseudoexfoliation syndrome in a population from the Republic of Korea.Semantic proximity Read ↗

Polymorphism rs10483727 in the SIX1/SIX6 Gene Locus Is a Risk Factor for Primary Open Angle Glaucoma in a Saudi Cohort.Semantic proximity Read ↗

Identification and genotype phenotype correlation of novel mutations in SIX6 gene in primary open angle glaucoma.Semantic proximity Read ↗

Genetic Link Across Species: SIX6, a Major Human Glaucoma Gene, Confers Susceptibility to Glaucoma in Shiba-Inu Dogs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.