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Genetic Link Across Species: SIX6, a Major Human Glaucoma Gene, Confers Susceptibility to Glaucoma in Shiba-Inu Dogs.

Investigative ophthalmology & visual science - 5 Jan 2026

Baba Satoko, Meguro Akira, Kanemaki Nobuyuki, Maeda Aoi, Takahashi Hiroki, Takeuchi Masaki, Endo Lisa, Nomura Eiichi, Nakamura Jutaro, Mizuki Yuki, Kanasashi Shun, Sakono Takuto, Yamada Norihiro, Mizuki Nobuhisa

Abstract excerpt

Purpose: The SIX6 gene is a major susceptibility gene for human glaucoma, and its variants have been implicated in structural and functional alterations of the retina, such as nerve fiber layer thinning and retinal ganglion cell degeneration, which contribute to glaucoma development. This study investigated whether SIX6 polymorphisms are associated with glaucoma in dogs, focusing on the Shiba-Inu and Shih-Tzu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41533905
DOI: 10.1167/iovs.67.1.5
PMCID: PMC12786397

Genes

SIX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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